Sirt1 nutrient signaling regulates fetal programming of nephrogenesis (1033.10)
نویسندگان
چکیده
منابع مشابه
SIRT1 Regulates Endothelial Notch Signaling in Lung Cancer
BACKGROUND Sirtuin 1 (SIRT1) acts as a key regulator of vascular endothelial homeostasis, angiogenesis, and endothelial dysfunction. However, the underlying mechanism for SIRT1-mediated lung carcinoma angiogenesis remains unknown. Herein, we report that the nicotinamide adenine dinucleotide 1 (NAD1)-dependent deacetylase SIRT1 can function as an intrinsic negative modulator of Delta-like ligand...
متن کاملPregnancy Recognition Signaling, Fetal-placental Development and Prenatal Fetal Programming
Contents 1. Introduction 2. Gene expression for uterine proteins and nutrient transporters 2.1. Temporal and spatial changes in steroid hormone receptors in the uterus during the peri-implantation period of pregnancy 3. Pregnancy recognition 3.1. Luteotrophic versus antiluteolytic signaling for pregnancy recognition 3.2. Corpus luteum formation and regression 3.3. Pregnancy recognition signals ...
متن کاملPhosphorylation Regulates SIRT1 Function
BACKGROUND SIR2 is an NAD(+)-dependent deacetylase [1]-[3] implicated in the regulation of lifespan in species as diverse as yeast [4], worms [5], and flies [6]. We previously reported that the level of SIRT1, the mammalian homologue of SIR2 [7], [8], is coupled to the level of mitotic activity in cells both in vitro and in vivo[9]. Cells from long-lived mice maintained SIRT1 levels of young mi...
متن کاملNotch signaling promotes nephrogenesis by downregulating Six2
During nephrogenesis, multipotent mesenchymal nephron progenitors develop into distinct epithelial segments. Each nephron segment has distinct cell types and physiological function. In the current model of kidney development, Notch signaling promotes the formation of proximal tubules and represses the formation of distal tubules. Here, we present a novel role of Notch in nephrogenesis. We show ...
متن کاملSirT1 Regulates Adipose Tissue Inflammation
OBJECTIVE Macrophage recruitment to adipose tissue is a reproducible feature of obesity. However, the events that result in chemokine production and macrophage recruitment to adipose tissue during states of energetic excess are not clear. Sirtuin 1 (SirT1) is an essential nutrient-sensing histone deacetylase, which is increased by caloric restriction and reduced by overfeeding. We discovered th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.28.1_supplement.1033.10